Models of causal reasoning based on an advanced theory of causal regularity explain causal reasoning in the history of science, and are the core of computational models for contemporary experimental research. Throughout history, science has been concerned with causal statements. The core methodology of empirical inquiry of causal regularities are experimental differential situations. Its experimental only outcome allows inferences about causal relevance between potential causal factors. This research theme focuses specifically on causality and causal reasoning in the history of science.