Representation of Validity as Hitting the Target

Representation of validity as hitting the target: amended to signify the challenge of validating a moving target. Source: Altered from Creative Commons: commons.wikimedia.org/wiki/File:Reliability_and_validity.svg. ©Nevit Dilmen CC-BY-SA

Max Planck Research Group (Biomedical Sciences)

Practices of Validation in the Biomedical Sciences

Research Group Leader

Lara Keuck

Room V102

What makes biomedical knowledge "specific", "sensitive", "reliable" or "valid" and how have scientists actually used these evaluative categories in practice throughout the twentieth century? These are the fundamental questions that the Max Planck Research Group “Practices of Validation in the Biomedical Sciences” studies with historical and philosophical methods.

Throughout the twentieth-century the credibility of biomedical knowledge has increasingly been coupled to methods for sampling, modelling and testing a vast range of objects of inquiry, such as cancerogenecity, schizophrenia or susceptibility to infectious diseases. These diverse targets are tied to specific theoretical assumptions and studied across petri dishes, animals, individual patients or populations. In order to choose between competing interpretations of tests and models for these biomedical targets, researchers have employed many different practices of “validation.”

In the twentieth century, the technical term "validity"—one with a complex genealogy from logic and statistics to psychology—was put to use in many sciences. The term denotes the extent to which an assessment of an item actually captures what it intends to capture: a "valid" intelligence test is thus informative about intelligence. For instance, introductions to psychometry often represent this idea of validity as hitting a target mark. In reconstructing the transdisciplinary foundations of validity and situating it in relation to that of other evaluative categories and methods, this research group examines how study results and diagnostic testing have been established, assessed, and regulated in modern biomedical research. 

Struggles for trustworthy biomedical knowledge have taken place amongst scientists and medical practitioners in various disciplinary and national contexts, in regulatory and funding agencies, and in response to public expectations and political decision-making. The group’s main aim therefore is to historicize validity as a relational property to understand how biomedical scientists have calibrated their methods vis-à-vis various challenges. Projects of the Max Planck Research Group investigate, for instance, how the heterogeneity of disease attributes has been conceived and contested by clinical researchers; or how the effects of the postwar growth and globalization of biomedical research have impacted on practices of validation. We currently coordinate two international Working Groups, one on translating validity in psychiatric research, and the other on the interplay between practices of validation and regulatory regimes across the health sciences. In following the reconfigurations of biomedical approaches to human health and disease, as well as of methods used to ascertain validity, we explore how biomedicine’s targets have been formed and moved through practices of validation.

Projects

Testing Chemicals and Validating Tests
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Translating Validity in Psychiatric Research
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News

Research Group Leader Lara Keuck co-organizes Wissensstadt Berlin event: "Remembering, differently?"

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Research Group "Practices of Validation in the Biomedical Sciences" seeks Predoctoral Fellow

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Research Group “Practices of Validation in the Biomedical Sciences” seeks Postdoctoral Fellow

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