Dynamics of scientific discovery processes are simulated by computational models. Computer models of scientific discovery have been studied since the 1960s as a key challenge towards replicating and understanding scientific problem solving. Initial models were too simple to capture the gist of scientific discovery. The discovery of the urea cycle by Hans Krebs and Kurt Henseleit was the first detailed simulation of experimental discovery that was investigated independently by Frederik Holmes, Herbert Simon, and Gerd Graßhoff.