This introduction to historical epistemology offers a general overview of the main themes, debates, and currents of this multifaceted field, which has emerged at the intersection of the philosophy of science and the history of science. The authors offer a historical reconstruction of the main debates that forged historical epistemology and assess today’s challenges. Additionally, they provide the reader with the conceptual and methodological tools that are necessary to enter this field and understand its main questions and approaches. This preprint is in Italian and available in print form only.